PearlAI

Exploit individual genetic changes for a successful outcome

Use breakthrough technology to predict cell-specific vulnerabilities that can be targeted by existing drugs.

PearlAI is a new drug prediction tool. We process mutation and gene expression data using the algorithm DependANT to provide personalised drug recommendations.

  • DependANT is a machine learning tool that predicts gene dependencies using individually modified Protein–protein interaction (PPI) networks
  • The algorithm is powered by data from DepMap
  • It adapts current PPI networks from the STRING database
  • These gene dependencies are then linked to drugs from ChemblDB that inhibit the relevant protein
  • We use the Clinical Trials API to find currently recruiting trials which your patient may be eligible for, offering drugs we recommend

At present PearlAI is available by invitation only. However, the team would like to engage with oncologists and other groups. If you are interested in helping us take forward this exciting work, please get in contact with Frances Pearl at f.pearl@sussex.ac.uk